| abstract |
Antibodies, humanized antibodies that have rearranged antibodies, antibody fragments, derivatized antibodies and their conjugates with cytotoxic agents that specifically bind to and inhibit insulin-like growth factor I receptor, inhibit IGF-I, IGF-II and serum on growth and survival tumor cells and which are essentially devoid of agonistic activity. These antibodies and fragments thereof may optionally be used together with other therapeutic agents in the treatment of tumors that express elevated levels of the IGF-I receptor, such as breast cancer, colon cancer, lung cancer, ovarian cancer, synovial sarcoma, prostate cancer , pancreatic cancer, and these derivatized antibodies can be used in the diagnosis and imaging of tumors that express elevated levels of the IGF-I receptor. |