| abstract |
A pyrimidone derivative having tau protein kinase 1 inhibitory activity represented by formula (I), or a salt thereof, or a solvate thereof, or a hydrate thereof; useful for the prophylactic and / or therapeutic treatment of diseases such as neurodegenerative diseases (eg, Alzheimer's disease); where Q represents CH or a nitrogen atom; R represents a C-alkyl group; the ring in formula (I) represents a piperazine ring or a piperidine ring; each X independently represents a C-C1-6alkyl group, an optionally partially hydrogenated C-Saryl ring, an indane ring or the like; m is an integer from 1 to 3; each Y independently represents a halogen atom, a hydroxy group, a cyano group, a C-alkyl group or the like; n is an integer from 0 to 8; if groups X and Y or two groups Y are attached to the same carbon atom, they can be combined with each other to form a C-alkylene group |