http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EA-009392-B1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5305109c4efec4cbcdd8bc05bdb00399 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D489-08 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D489-08 |
| filingDate | 2005-08-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cc66c2119dfe9218532e772c1a9147f8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6078fdc168be625c1a3e33b6e35a8319 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_daf383117f7c0a1bf62cedf2128bc870 |
| publicationDate | 2007-12-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EA-009392-B1 |
| titleOfInvention | METHOD OF OBTAINING OXYCODON |
| abstract | A process for the preparation of oxycodone of formula I, wherein thebaine of formula II or an analogue of formula III is reacted, wherein R is C-C1-6alkyl, alkylaryl, preferably benzyl, methoxybenzyl or allyl, with hydrogen peroxide or peroxo acids in the presence of oxalic acid mixed with acetic or formic acid. From the resulting crystalline precipitate of 14-hydroxycodeinone oxalate, the addition of a base gives 14-hydroxycodeinone of formula IV, which is hydrogenated with hydrogen in the presence of a catalyst to produce oxycodone (I). Oxycodone is converted to hydrochloride, which is used as the active ingredient in painkillers. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2639877-C2 |
| priorityDate | 2004-08-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 67.