| abstract |
The present invention relates to a compound of formula I in which A represents a phenyl group and the like; B represents an aryl group and the like; E represents a 1,4-phenylene group; R and R independently represent a hydrogen atom and the like; R and R independently represent a hydrogen atom and the like; R represents-DREAM, etc .; R represents an alkyl group having from 1 to 6 carbon atoms and the like; X represents a methylene group and the like. These compounds can be used to treat prostaglandin-mediated pathological conditions, such as pain or the like, in a mammal. These compounds act as prostaglandin E2 receptor antagonists. The present invention also relates to a pharmaceutical composition comprising the compound described above. |