| abstract |
The invention relates to nicotinamide derivatives of the formula (1) and to methods for producing such derivatives, to intermediate compounds used in the preparation of such derivatives, to compositions containing such derivatives, and to their uses. The nicotinamide derivatives of the present invention are inhibitors of phosphodiesterase-4 and are useful in various diseases, disorders and conditions, in particular in inflammatory, allergic, respiratory diseases, disorders and conditions, as well as in wounds. |