| abstract |
Pharmaceutical compositions and methods are disclosed comprising at least one compound representing a YY peptide and one or more agents promoting intranasal delivery for improved delivery of a YY peptide through mucous membranes of the nasal cavity in order to treat a large number of diseases and conditions, including obesity, in mammalian subjects. In one aspect, these preparations and intranasal delivery methods provide improved delivery of a YY peptide to a blood plasma or tissue or central nervous system (CNS) fluid, for example, to produce a peak concentration (C) of a YY peptide in a blood plasma or tissue or fluid The central nervous system of the subject is 20% or higher compared to the peak concentration of the YY peptide in the blood plasma, or tissue, or fluid of the central nervous system of the subject after administration to the subject of the same concentration or dose of the YY peptide by subcutaneous injection. |