| abstract |
This invention relates to potent taxanes having a binding group. Also, the present invention relates to a cytotoxic agent containing one or more taxonom coupled to an agent that binds cells. In addition, the present invention relates to a pharmaceutical composition intended to induce cell death in a selected population, comprising: (A) a cytotoxic amount of one or more taxane covalently linked to an agent that binds cells through a binding group, and (B) a pharmaceutically available carrier, diluent or filler. The present invention also relates to a method of inducing cell death in selected populations, consisting in the treatment of target cells or tissues containing target cells with an effective amount of a cytotoxic agent containing one or more taxan linked to a cell-binding agent. |