| abstract |
The present invention relates to compounds of the formula (I-A) and (I-B). In a preferred embodiment, X is O; R 1 is C 1-6 alkyl; cycloSalkyl or (cycloSalkyl) C1-6alkyl, wherein one or more hydrogen atoms in the C1-6alkyl or cycloalkylalkyl moieties may optionally be substituted by C1-6alkyloxy, aryl, halogen or thienyl; Is hydrogen; halogen; C1-6alkyl or amino; R and R are independently hydrogen or C1-6alkyl; either R and R, taken together, can form a —RR— group, which is a divalent radical of the formula —Z — CH — CH — CH— or —Z — CH — CH—, where Z is O or NR, where R is C 1-6 alkyl, each divalent the radical is optionally substituted with C1-6alkyl; or R and R, taken together, can form a divalent radical of the formula —CH — CH — CH — CH — CH—; Is hydrogen; Y represents O; and aryl is phenyl optionally substituted with halogen. The present invention also relates to the use of a compound of this invention as a medicament and to the manufacture of a medicament for the treatment or prophylaxis of glutamate-induced diseases of the central nervous system, as well as to pharmaceutical preparations containing such a compound, and to methods for producing such a compound. |