| abstract |
The present invention relates to inhibitors of HIV replication of formula (I), their N-oxides, pharmaceutically acceptable additive salts, quaternary amines or stereochemically isomeric forms, where the ring containing -a = aa = a- and -b = bb = b- is phenyl, pyridyl, pyrimidinyl, pyrazinyl, pyridazinyl; n is 0-5, m is 1-4; R1 is hydrogen; aryl; formyl; C1-6 alkylcarbonyl; Calkyl; C1-6alkyloxycarbonyl; substituted C1-6 alkyl; C1-6alkylcarbonyl; R 3 is hydroxy, halogen, optionally substituted C 1-6 alkyl, C 1-6 cycloalkyl, optionally substituted C 1-4 alkenyl, optionally substituted C 1-6 alkyl, C 1-6 alkyloxy, C 1-6 alkyloxycarbonyl, carboxyl, cyano, nitro, amino, mono- or di (C 1-6 alkyl) amino, polyhalomethyl, 2-methylmethyloxy, polyhalogenomethyl, alkoxy, mono- or di (Calkyl) amino, polyhalomethyl, hydroxymethyloxy, carbonyl, cyano, nitro, amino, mono- or di (C1-6alkyl) amino, polyhalomethyl, hydroxymethyloxy, carbonyl, cyano, nitro, amino; = O) R, -NH-S (= O) R, -C (= O) R, -NHC (= O) H, -C (= O) NHNH, -NHC (= O) R, C (= NH) R5 is a 5-membered heterocycle; X represents -NR, -NH-NH-, -N = N-, -O-, -C (= O) -, Calkandiyl, -CHOH-, -S-, -S (= O) -, -Х- Salkandiyl- or -Salkandiyl-X-; R represents NHR; NRR; -C (= O) -NHR; -C (= O) -NRR; -C (= O) -R; -CH = N-NH-C (= O) -R, substituted C1-6alkyl, optionally substituted C1-6alkyloxy; substituted Salkenyl, substituted Salkynyl, C1-6 alkyl, substituted with hydroxy and a second substituent; —C (= N — O — R) —C alkyl; R or XR; R1 is halogen, hydroxy, C1-6alkyl, Cycloalkyl, C1-6alkyloxy, cyano, nitro, polyhaloalkyl, polyhalo-C1-6alkyloxy, aminocarbonyl, C1-6alkyloxycarbonyl, C1-6alkylcarbonyl, formyl, amino, mono- or di (C1-6alko) amino; their use as a medicine, methods for their preparation and pharmaceutical preparations containing them. |