| abstract |
The invention relates to compositions containing physiologically active compounds of the general formula (I) wherein R 1 is aryl or heteroaryl; R represents a hydrogen atom, an acyl group, a cyano group, a halogen atom, Salkenyl or C1-6alkyl optionally substituted with a substituent selected from cyano group, heteroaryl, heterocycloalkyl, -ZR, -C (= O) -NYY, -COR, -NYY, -N (R) -C (= O) -R, -N (R) -C (= O) -NYY, -N (R) -C (= O) -OR, -N (R) -SO-R, -N ( R) —SO — NYY and one or more halogen atoms; R represents a hydrogen atom, an aryl, a cyano group, a halogen atom, heteroaryl, C1-6alkyl, -C (= O) -OR or -C (= O) -NYY; and X is N, CH, C-halogen, C-CN, C-R, C-NYY, C-OH, C-ZR, CC (= O) -OR, CC (= O) -NYY, CN (R) -C (= O) -R, C-SO-NYY, CN (R) -SO-R, C-alkenyl, C-alkynyl or C-NO; with the proviso that when R represents phenyl or substituted aryl, R represents C1-6alkyl substituted with —C (= O) —NYY, —N (R) —C (= O) —R, —N (R) —C (= O) - NYY or NYY or R represents Salkenyl, and R represents a hydrogen atom, a halogen atom or C1-6alkyl, then X has a value other than CH; and their prodrugs, and pharmaceutically acceptable salts, and solvates of such compounds, and their prodrugs; as well as new compounds within the scope of formula (I). Such compounds and compositions possess valuable pharmaceutical properties, in particular the ability to inhibit protein kinases. |