| abstract |
The present invention relates to polynucleotide molecules containing nucleotide sequences encoding an aveC gene product, and these polynucleotide molecules can be used to alter the ratio or amount of 2: 1 class avermectins produced in S.avermitilis fermentation cultures. In addition, the present invention relates to vectors, host cells and mutant strains of S.avermitilis, in which the aveC gene is inactivated or mutated in such a way as to change the ratio or amount of produced 2: 1 class Avermectins. |