| abstract |
The present invention relates to compounds of the general formula (I) wherein Ar is aryl or heteroaryl; n is 0 or 1; T, U, V and W independently represent a nitrogen atom or an optionally substituted methine group, at least two of which represent said methine group; X represents methine or nitrogen; Y represents an optionally substituted imino group or an oxygen atom; and the like. The compounds of the present invention exhibit NPY antagonistic activity and are useful as agents for treating various diseases associated with NPY, for example, cardiovascular disorders such as hypertension, nephropathy, heart disease, vasospasm, arteriosclerosis and the like, central nervous system disorders such as bulimia, depression, anxiety, seizure, epilepsy, dementia, pain, alcoholism, drug withdrawal syndrome and the like, metabolic disorders such as obesity, diabetes, hormonal disorder, hyperchole erinemiya, hyperlipidemia and the like, sexual and reproductive dysfunction, gastrointestinal disorders, respiratory diseases, inflammation, or glaucoma, and the like. |