http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EA-004435-B1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_cffb44082220de55d755db0cc471fd4d |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-44 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4418 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-12 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D211-84 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4422 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-44 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D207-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-40 |
| filingDate | 2000-04-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2004-04-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EA-004435-B1 |
| titleOfInvention | SYNERGISTIC ACTION OF AMLODIPINE AND ATORVASTATIN METABOLITIS AS A BASIS FOR COMBINED THERAPY |
| abstract | The combination of amlodipine with the metabolite of atorvastatin has a synergistic antioxidant effect on lipid peroxidation in human low density lipoproteins and in membrane vesicles enriched with polyunsaturated fatty acids. The degree of inhibition by this combination of drugs of damage caused by oxy radicals with therapeutic amounts of drugs administered could not be repeated with the combination of amlodipine with other statins or with the natural antioxidant vitamin E. It was concluded that the chemical structures of the compounds and their molecular structures are the basis of this high activity interaction with phospholipid molecules, which confirms the analysis using x-ray scattering. This combination therapy can be used to treat cardiovascular diseases, especially coronary artery disease, by increasing the resistance of oxidative modification of low density lipoproteins and vascular cell membranes. |
| priorityDate | 1999-04-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 59.