| abstract |
The invention relates to compounds, compositions and methods related to the arylsulfonamide derivatives of formula (I) or their pharmaceutically acceptable salts, where Ar is a substituent selected from the group consisting of (a), (b), (c) and (d) , and their use as pharmacologically active agents. The compositions find particular use as pharmacological agents in the treatment of disease states, in particular cancer, psoriasis, vascular restenosis, infections, atherosclerosis and hypercholesterolemia, or at least as compounds for the development of such agents. |