| abstract |
The present invention provides PEG-β-interferon conjugates, wherein the PEG portion is covalently linked to human C-interferon Cys, which is obtained by the site-specific PEG attachment method with an agent for introducing PEG having a reactive thiol group. A pharmaceutical composition and method for the treatment of infectious diseases, tumors and autoimmune and inflammatory diseases are also presented. The invention further relates to a method for stepwise attachment of PEG moieties to the polypeptide in series, and especially to β-interferon. |