| abstract |
The present invention relates to prodrugs of the sulfonamide class, which are aspartyl protease inhibitors. In one embodiment, this invention relates to a new class of prodrugs that are inhibitors of HIV aspartyl proteases, characterized by good water solubility, high oral bioavailability and easy in vivo reproduction of the active component. This invention also relates to pharmaceutical compositions containing these prodrugs. The prodrug and pharmaceutical preparations of this invention are most suitable for reducing drug loading and greater patient convenience. The invention also relates to methods for treating mammals with these prodrugs and pharmaceutical compositions. |