| abstract |
The compounds of formula (1), or a salt thereof, or non-toxic metabolically labile esters, where Y represents a carbon atom, Z represents a CH group that is linked to the Y group via a double bond, and X represents CH, or Z represents methylene or NR, and X represents a carbon atom bonded to group Y via a double bond, A represents a C 1-6 alkylene chain which may be substituted with one or two groups selected from C 1-6 alkyl, optionally substituted with hydroxy, amino, C 1-6 alkylamino amino, or may be substituted by = O, R represents a halogen atom or a C 1-6 alkyl group, R 1 represents a hydrogen atom, a halogen atom or a C 1-6 alkyl group, R 1 represents a possibly substituted phenyl, 5 membered heteroaryl group containing from 1 to 3 heteroatoms selected from oxygen, sulfur and nitrogen, or a 6-membered heteroaryl group containing from 1 to 3 nitrogen atoms, methods for their preparation and their use as glycine antagonists. |