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filingDate 1998-09-22-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4bfff66135e1457025a454f910ebca35
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publicationDate 2001-12-24-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber EA-002030-B1
titleOfInvention POLYMERIC DERIVATIVES OF CAMPTOTECINES
abstract Camptothecin water soluble polymeric conjugates include N- (2-hydroxypropyl) methacryloylamide units linked through a spacer of the formula -Gly- (CH) -CO-Gly, where n = 2-8 to the C-20 position of the camptothecin residue. Conjugates have increased anti-tumor activity and less toxicity than free drug. The method for their preparation and the pharmaceutical compositions containing them are also described.
priorityDate 1997-10-03-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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