| abstract |
The compound of formula (I), where R represents a 2-dimethylaminoethoxy group or a group of the formula G, G, G, G or G; R 1 is hydrogen, (C — C) alkyl, phenyl or naphthyl, wherein said phenyl or naphthyl may be optionally substituted with one or more substituents, preferably 0 to 3 substituents independently selected from chloro, fluoro, bromo, iodo, (C — C) alkyl, (C — C) alkoxy, trifluoromethyl, cyano and SO (C — C) alkyl, where g is 0, 1 or 2; R is (CH) B, where m is 0, 1, 2 or 3, and B is hydrogen, phenyl, naphthyl or a 5- or 6-membered heteroaryl group containing one to four heteroatoms in the ring (e.g., furyl, thienyl, pyridyl, pyrimidyl, thiazolyl, pyrazolyl, isothiazolyl, oxazolyl, isoxoxazolyl, pyrrolyl, triazolyl, tetrazolyl, imidazolyl, etc.), and where each of the above aryl and heteroaryl groups may be optionally substituted with one or more substituents, preferably substituents from 0 to 3 independently selected from x loro, fluoro, bromo, iodo, (C — C) alkyl, (C — C) alkoxy, trifluoromethyl, cyano, hydroxy, COOH and SO (C — C) alkyl, where g is 0, 1 or 2; Z represents CRR, where R and R are independently selected from hydrogen, (C — C) alkyl and trifluoromethyl, or Z may be one of the aryl or heteroaryl groups described above in definition B, where two adjacent members of the ring Z are also members of the ring A; X represents hydrogen, chloro, fluoro, bromo, iodo, cyano, (C — C) alkyl, hydroxy, trifluoromethyl, (C — C) alkoxy, SO (C — C) alkyl, where g is 0, 1 or 2, COR or CONRR, each of R, R and R is independently selected from the radicals indicated previously in the definition of R; or R and R, together with the nitrogen to which they are attached, form a ring containing from 5 to 7 members, which may contain from 0 to 4 heteroatoms selected from nitrogen, |