| abstract |
Succinamide derivatives of formula (I) in which W represents a —COH or —CONHOH group, each R, R and R represents hydrogen or an organic residue, R represents an alpha amino acid residue and R represents an organic group, are inhibitors of matrix metalloproteinases (MMPs) and factor release from cells alpha tumor necrosis (TNF), so they can be effectively used for the prevention and treatment of diseases caused by MMP or TNF. The invention also relates to pharmaceutical compositions containing said compounds. |