http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EA-001385-B1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e6dbc8af1157a8bba7d30d053437b371 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5b459ec3f5254c20ccd5ca24931c4610 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D305-14 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D305-14 |
| filingDate | 1997-02-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e5b81490a5afc41e92262fdaeb437046 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_74a154a30a6d83e6622da07343ccad2a |
| publicationDate | 2001-02-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EA-001385-B1 |
| titleOfInvention | INTERMEDIATE CONNECTION FOR USE IN THE SYNTHESIS OF A DOCETAXEL AND METHOD OF ITS OBTAINING |
| abstract | C7, C10 di-CBZ 10-deacetylbaccatin III is provided as an intermediate for the preparation of docetaxel. Provided is a method for preparing this C7, C10 di-CBZ 10-deacetylbaccatin III. In this process, 10-deacetylbaccatin III is acylated with at least 1.5 equivalents of n-butyllithium and at least 1.5 equivalents of benzyl chloroformate in tetrahydrofuran. 10-Deacetylbaccatin III can first be dissolved in tetrahydrofuran, after which n-butyllithium is added followed by benzyl chloroformate. The reaction takes place preferably at a reduced temperature below -20 ° C. The resulting solution can be quenched with ammonium chloride and concentrated to a residue. The residue can then be redissolved in an organic solvent, washed, dried and recrystallized to purify the compound. |
| priorityDate | 1996-02-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 52.