http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EA-000831-B1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3c82fea9cd3dc48540ebd26d3b952479 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D295-205 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D295-088 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D295-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D295-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D295-205 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D295-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D295-088 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D295-08 |
| filingDate | 1997-03-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ce64e9363a3fee8f7a9ebb815d495908 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0c8f8990d313e47942fd41a5bde3966d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ac60606995814e0c9066dddbc5f4d940 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f0efbf275272c2738d7311cac04e3f67 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_df3b91fe43411460559e70414dd5debd |
| publicationDate | 2000-04-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EA-000831-B1 |
| titleOfInvention | SUBSTITUTED [2- (1-PIPERASINYL) ETOXI] METHYL COMPONENTS, METHOD OF THEIR PREPARATION AND THEIR APPLICATION |
| abstract | 1. Novel substituted [2-(1-piperazinyl)ethoxy]methyl compounds of formula (I) wherein R1 is -CONH2, -CN, -COOH, -COOM or -COOR3, where M is an alkali metal and R3 is C1-C4 alkyl; and R2 is a hydrogen atom ome or a -COR4 or -R5 group, where R4 is selected from -OR6 or -R7 groups, wherein R5 is allyl or alkylaryl, R6 is a straight or branched C1-C4 alkyl, halogenoalkyl, alkylaryl, alkylnitroaryl or alkylhalogenoaryl, and R7 is halogenoalkyl 2. A substituted [2-(1-piperazinyl)ethoxy]methyl compound of claim 1, wherein selected from 2-(l-piperazinyl)ethoxyacetic acid, 2-[2-(l-piperazinyl)ethoxy]acetamide, 2-(l-piperazinyl)ethoxyacetonitrile, 2-(1-piperazinyl)ethoxyacetatemethyl, 2-(l-piperazinyl)ethoxyacetateethyl, 2-(4-benzyl-1-piperazinyl)ethoxyacetamide, 2-(4-benzyl-1-piperazinyl)ethoxyacetonitrile, 2-(4-benzyl-l-piperazinyl)ethoxyacetatemethyl, 4-(2-carbamoylmethoxyethyl)-piperazine-1-carboxylatebenzyl, 4-(2-cyanomthoxyethyl)-piperazine-l-carboxylatebenzyl, 4-(2-carbamoylmethoxyethyl)-piperazine-l-carboxylatetertbutyl, 4-(2-cyanomethoxyethyl)-piperazine-1-carboxylatetertbutyl, 4-(2-methoxycarbonylmethoxyethyl)-piperazine-l-carboxylatetertbutyl, 4-(2-carbamoylmethoxyethyl)-piperazine-1-carboxylateethyl, 2-(4-carboxyethyl-1-piperazinyl)ethoxyacetatepotassium. 3. A substituted [2-(1-piperazinyl)ethoxy]methyl compound of claim 1, wherein the group protecting R2 amine function is a straight or branched alkylcarboxylate group, containing 1 to 4 carbon atoms, or a alkylaryl group. 4. A method for preparing [2-(l-piperazinyl)ethoxy]methyl of claims 1-3, wherein the piperazine of formula wherein R2 is a hydrogen atom or -COR4 or R5, wherein R4 is selected from -OR6 or -R7 groups, in which R5 is allyl or alkylaryl radical, R6 is a straight or branched alkyl radical, containing 1 to 4 carbon atoms, halogenoalkyl, alkylaryl, alkylnitroaryl or alkylhalogenoaryl, R7 is halogenoalkyl reacts with a substituted [2-haloetoxy]methyl compound of formula X-CH2-CH2-O-CH2-R1 wherein R1 is -CONH2, -CN, -COOH, -COOM or -COOR3 group, M is an alkali metal, R3 is C1-C4 alkyl and X is a halogen atom. 5. A method of claim 4, wherein a halogen atom designated as X is chlorine or iodine. 6. A method of claim 4 or 5, wherein the protection group for R2 amine function is a straight or branched alkyl carboxylate group, containing 1 to 4 carbon atoms, or alkylaryl group. 7. Use of a substituted [2-(1-piperazinyl)ethoxy]methyl compounds of formula wherein R1 is -CONH2, -CN, -COOH, -COOM or -COOR3 group, M is an alkali metal, R3 is C1-C4 alkyl and R2 is a hydrogen atom as an intermediate product for preparing compounds of formula wherein R1 has the above value in formula (I) and X1 and X2 are independently hydrogen, fluoro, chlorine and/or bromine. 8. A method for preparing compounds of formula R1 is -CONH2, -CN, -COOH, -COOM or -COOR3 group, M is an alkali metal, R3 is C1-C4 alkyl and X1 and X2 are independently hydrogen, fluoro, chlorine and/or bromine, wherein a substituted [2-(1-piperazinyl)ethoxy]methyl compound of formula wherein R1 is -CONH2, -CN, -COOH, -COOM or -COOR3 group, M is an alcali metal, R3 is C1-C4 alkyl and R2 is a hydrogen atom, reacts with diphenylmethanehalogenide of formula wherein X is halogen, selected from chlorine, bromine or iodine and X1 and X2 are independently hydrogen, fluoro, chlorine and/or bromine. 9. A method of claim 8, wherein a substituted [2-(l-piperazinyl)ethoxy]methyl of formula (I), wherein R2 is a hydrogen atom and is a product of the cleavage reaction of the R2 group a substituted [2-(l-piperazinyl)ethoxy]methyl of formula (I), wherein R2 is a hydrogen atom or -COR4 or R5 group, where R4 is selected from OR6 or R7 groups, wherein R5 is allyl or alkylaryl radical, R6 is a straight or branched alkyl radical, containing 1 to 4 carbon atoms, halogenoalkyl, alkylaryl, alkylnitroaryl or alkylhalogenoaryl, R7 is halogenoalkyl. 10. Use of the compounds of formula wherein R1 is -CONH2, -CN, -COOH, -COOM or -COOR3 group, M is an alkali metal, R3 is C1-C4 alkyl and X1 is a chlorine atom in position 4 and X2 is a hydrogen atom obtained by a method of claim 8 as intermediate compounds for preparing 2-[2-[4-[(4-chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxylacetic acid and/or pharmaceutically acceptable salts thereof. 11. Use of the compounds of formula wherein R1 is -CONH2, -CN, -COOH, -COOM or -COOR3 group, M is an alkali metal, R3 is C1-C4 alkyl and X1 and X2 each is a fluoro atom in position 4, obtained by a method of claim 8 as intermediate compounds for preparing 2-[2-[4-[bis(4-fluorophenyl)phenylmethyl]-1-piperazinyl]ethoxyacetic acid and/or pharmaceutically acceptable salts thereof. |
| priorityDate | 1996-04-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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