| abstract |
The present invention relates to compounds of formula (I) derived from spiro 1',2''-imidazole and their pharmaceutical compositions. An example of these compounds is the compound of formula Likewise, the present invention relates to the use of these compounds as beta-secretase inhibitors (BACE) for the treatment and/or prevention of pathologies related to Aβ, such as Down syndrome, ß-amyloid angiopathy such as, but not limited to, cerebral amyloid angiopathy or hereditary cerebral hemorrhage, disorders associated with cognitive impairment, such as, but not limited to, MCI ("mild cognitive impairment"), Alzheimer's disease, memory loss, symptoms of attention deficit associated with Alzheimer's disease, neurodegeneration associated with diseases such as Alzheimer's disease or dementia, including dementia of vascular and mixed degenerative origin, presenile dementia, senile dementia and dementia associated with Parkinson's disease, progressive supranuclear palsy or corticobasal degeneration. |