| abstract |
The present invention relates to a composition for the prevention or treatment of diabetes which includes a long-acting insulin conjugate and a long-acting insulinotropic peptide conjugate, and a method for treating diabetes. More specifically, the administration of the combination of the long-acting analog conjugate and the long-acting insulinotropic peptide conjugate inhibits weight gain due to insulin administration, and vomiting and nausea due to insulinotropic peptide administration, and also reduces the required dose of insulin, thereby significantly improving the observance of the drug. In addition, the present invention relates to the administration of a pharmaceutical composition for reducing side effects of pancreatic beta cells in diabetic patients, which includes a long-acting insulin analogue conjugate and a long-acting insulinotropic peptide analog conjugate, and a method to reduce the side effects of pancreatic beta cells in diabetic patients, which includes the stage of administering the composition. Specifically, the present invention is characterized by the reduction of side effects such as the anomaly in the function of pancreatic beta cells associated with the development of diabetes, reduction of the mass of pancreatic beta cells, lipotoxicity or glucotoxicity. |