| abstract |
A human antibody or antigen-binding fragment of a human antibody that specifically binds and inhibits human type 9 subtyiisin / kexin convertase (hPCSK9) proprotein characterized by the ability to reduce serum LDL cholesterol by 40-80% for a period of time. 24, 60 or 90 day period with respect to pre-dosing levels, with a small or no reduction in serum HDL cholesterol and / or with a small or non-measurable effect on liver function, as determined by the measures of ALT and AST. |