| abstract |
The invention relates to derivatives of 1-aminophthalazine, of general formula (I): wherein A, B = alkylene-Cl-4, optionally substituted; L = single bond or C1-2 alkylene, -CH = CH- optionally substituted, or -C = C-, or cycloprop-l, 2-diyl; R1 = optionally substituted aryl or heteroaryl; R2, R3 = H, C3-3 alkyl, C1-3 fluoroalkyl or R2 and R3 together form, with the carbon atom that carries them, a cycloprop-1, 1-diyl; R4 = H, C1-5 alkyl, fluroalkyl-C1-3, cycloalkyl-C3-6, cycloalkyl-C3-6-alkylene-C1-3, alkyl-C, 1-3-0-alkylene-Cl-3, HO-C1-3-alkylene, Cl-3-X-alkylene-Cl-3 alkyl wherein X = S, SO or S02; or R4, = RaRbN-alkylene-Cl-3, aryl, aryl-alkyleneCl-3, aryl-O, aryl-O-C1-3 alkylene; aryl-alkylene-Cl-3-Oalkylene-Cl-3, heteroaryl or heteroaryl-C1-3 alkylene; R5 = H, halogen, C1-5 alkyl, fluoroalkyl-Cl-3, alkoxy-Cl-5, fluoroalkoxy-C1-3, HO-C1-3 alkylene, -CN, C1-3-X alkyl where X = S, SO or S02; or R5 = RaRbN-, RaRbN-C1-3 alkylene, aryl, aryl-C1-3 alkylene, aryl-O- or heteroaryl; R6 = H, halogen, C1-5 alkyl, C1-3 fluoroalkyl, C1-5 alkoxy, C1-3 fluoroalkoxy, -CN, RaRbN-, RaRbN-C1-3 alkylene, aryl or heteroaryl; R7 = H, halogen, C1,5 alkyl, fluoroalkyl-C1-3, alkoxy-Cl-5, fluoroalkoxy-C1-3, HO-alkylene-Cl-3, -CN, alkyl C1-3-X- where X = S, SO or SO2; or RaRbN-, RaRbN-alkylene-C, 3, RaRbNC (0) -, C1-3-C alkyl (0) -, aryl, aryl-O- or heteroaryl; RB = H, halogen, C1-5 alkyl, C1-5 alkoxy, C1-3 fluoroalkoxy; in the base or salt state of addition of an acid, as well as in the state of hydrate or solvate. Procedure of preparation and application in therapy. |