http://rdf.ncbi.nlm.nih.gov/pubchem/patent/DK-3066071-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_71b944100daf03103e6704d7474fd127 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-582 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C201-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C231-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C227-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F5-025 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F5-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F5-05 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C237-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C237-46 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C231-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C231-12 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C231-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F5-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F5-02 |
| filingDate | 2014-11-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2018-07-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ad1726b310bdcf96a81a95823b618796 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bd1b0b6b5487a9c3b488b3afad748a0b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4ae6ad06847e3e0eca7f084c34e2cd4d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8793e6319adb328d35dcb34993e823e3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_26af1d3be53ce309af2169b415eb6006 |
| publicationDate | 2018-07-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | DK-3066071-T3 |
| titleOfInvention | METHOD OF PREPARING IOPAMIDOL |
| abstract | The present invention discloses a process for the preparation of lopamidol of formula (II)n nand comprising the following steps:na) reacting the Compound (I) wherein X is OR 2 or R 3 , and wherein R 2 and R 3 are a C 1 -C 6 linear or branched alkyl, C 3 -C 6 cycloalkyl, C 6 aryl, optionally substituted with a group selected from the group consisting of methyl, ethyl, n-propyl, i-propyl, n-butyl, sec-butyl, t-butyl and phenyl, with the acylating agent (S)-2-(acetyloxy)propanoyl chloride in a reaction medium to provide the acetyloxy derivative of Compound (I);nb) hydrolyzing the intermediate from step a) with an aqueous solution at a pH comprised from 0 to 7, by adding water or a diluted alkaline solution such as sodium hydroxide or potassium hydroxide, freeing the hydroxyls from the boron-containing protective groups, obtaining the N-(S)-2-(acetyloxy)propanoyl derivative of Compound (II);nc) alkaline hydrolysis to restore the (S)-2-(hydroxy)propanoyl group and to obtain lopamidol (II) and optional recovery of the boron derivative from the solution obtained in step b).nThe boron-containing protective group is versatile, efficient and recyclable. A one-pot synthesis, without intermediate isolation is provided, leading to a decreasing of recovered and recycled solvents and a significant increasing in the yield, representing a significant advantage in terms of cost-effectiveness of the entire process and environmental awareness. |
| priorityDate | 2013-11-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 158.