| abstract |
The present invention relates to an exendin-4 analogue PEGylated with polyethylene glycol or a derivative thereof, a preparation method thereof, and a pharmaceutical composition for preventing or treating diabetes, containing the same as an active ingredient. According to the present invention, it is possible to increase the yield of a PEGylated exendin-4 analogue and to enhance the therapeutic effect of a drug through the selective PEGylation of cysteine using exendin-4 in which said cysteine (Cys) is introduced at position 40 of the C terminal, and thus it is possible to usefully employ the same in a composition for preventing or treating diseases caused by the hypersecretion of insulin. |