| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8528ff66470c896b6da8ed059464e31f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ce3d57a6fc2fad533ce367f648d280ec |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-437
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-422
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K67-0275 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-28
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-437
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-422
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A01K67-027 |
| filingDate |
2011-10-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2018-01-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_efc17a68d0497dd35271eb56269bf6fd
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e83e963c4a2a5a86f4b58ad8330e029d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4d49727db88d2b0985e812ad0cec2a8c |
| publicationDate |
2018-01-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
DK-2624832-T3 |
| titleOfInvention |
HDAC INHIBITORS FOR TREATMENT OF CHARCOT-MARIE-TOOTHS DISEASE |
| abstract |
The present application relates to diseases in the peripheral nervous system, particularly hereditary neuropathies, most particularly, Charcot-Marie-Tooth (CMT) disease. It is shown that this disease is associated with decreased acetylated tubulin levels, which can be overcome by inhibition of histone deacetylases (HDACs). Using HDAC inhibitors, it is shown herein that the symptoms of the CMT phenotype can be overcome both in vitro and in vivo. Also provided herein are two different mouse models of CMT disease. |
| priorityDate |
2010-10-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |