http://rdf.ncbi.nlm.nih.gov/pubchem/patent/DK-175240-B1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d202e9e866984fe229f6facc38f1d740 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J73-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J75-00 |
| filingDate | 1998-04-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2004-07-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e1e42bc60c5f6a9eb380f35b534db41c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2789721c42d772ecce858eb194142854 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9c37ee0e6c283f66ff94ea47d836f7e0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b4a3190e54d6e76d73d3033ef485b757 |
| publicationDate | 2004-07-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | DK-175240-B1 |
| titleOfInvention | Crystalline 17beta (N-tert-butylcarbamoyl) -4-aza-5alpha-androst-1-en-3-one and process for preparation thereof, pharmaceutical composition containing the compound and use of the compound to prepare a medicament for treatment |
| abstract | Steroid derivs. of formula (I) are new, where Q is absent or is a benzoquinone gp. of formula (Q') or (Q''), where T = H or Si(R4)3; each R4 = opt. branched 1-8C alkyl, 3-6C cycloalkyl or phenyl; R14 = H, 1-6C alkyl, opt. branched 1-6C alkoxy, halogen, NO2 or CN; B is (a) when Q is present: -CO-X-; X = NR1, O or CH2; R1 = H, Me or Et, or is absent; B is (b) -C(OSi(R4)3)=X'-; or X' = N or CH; B is (c) =C(OSi(R4)3)-X''-; or X'' = O or CH2; Z = (1) beta-H, alpha-OH; or Z = (2) alpha-H or alpha-OH and (a) -Alk-CO-R8 or -CO-R8; or (b) -Alk-OR12; Alk = opt. branched 1-12C hydrocarbon chain; R8 = H, OH, 1-12C alkyl, NR9R10 or OR11; R9, R10 = H, opt. branched 1-12C alkyl (opt. having an OH, COOH or 1-4C alkoxycarbonyl substit.), 3-6C cycloalkyl or phenyl; or NR9R10 = 5- or 6-membered satd. ring opt. contg. a further O or N heteroatom; R'' = H, alkali metal, opt. branched 1-18C alkyl or benzyl; R12 = phenyl-(1-6C)alkylcarbonyl, 5-10C cycloalkylcarbonyl, benzoyl, 1-18C alkoxycarbonyl, aminocarbonyl or 1-8C alkyl substd. aminocarbonyl, or is H provided that Alk = branched 3-8C chain; or Z = (3) =CH-(Alk)-CO-R8 or =CH-(Alk)-OR12a; (Alk) = bond or Alk as above; R12a = R12, H or 1-20C alkylcarbonyl; or Z = (4) gp. of formula (Z'), where the dashed bond replaces the 17alpha-H; or Z = (5) alpha-H and -NHCO-R13; R13 = 1-12C alkyl or -NR9R10; Z = (6) alpha-H and CN; or Z = (7) alpha-H and tetrazolyl; R' = H or Me; R'' = H or beta-Me; R''' = H, beta-Me or OH. Also claimed is a process for dehydrogenating a steroid deriv. of formula (I') which comprises reacting the cpd. with a silylating agent in the presence of a quinone to introduce a delta-1 double bond. |
| priorityDate | 1987-06-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 72.