http://rdf.ncbi.nlm.nih.gov/pubchem/patent/DK-174517-B1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_42e94091a4fc81b8d0237117707cc7ee |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D501-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D501-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D501-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D501-59 |
| filingDate | 1988-04-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2003-05-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7e1f7fbb1fc08fd4a58ffb6b24f0692d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_18df591212f639f4cb0db566c78819ae http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_148ebd4feaf8882056624b23b960e1f1 |
| publicationDate | 2003-05-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | DK-174517-B1 |
| titleOfInvention | Process for preparing 3-hydrocarbyl-3-cephem derivatives |
| abstract | Prepn. of 3-hydrocarbyl-3- cephem-4-carboxylic acids of formula (I) or their salts or esters comprises: (i) providing a 3-trifjluromethane su,lsulphonloxy-3-cephem (II) starting cpd. in a relatively polar aprotic solvent; (ii) contacting this with an at least equimolar amt. of R1-trialkyl stannane (III) in presence of 1-10 mole% of a Pd(O) or Pd (II) cpd. and 3-30 mole.% of tri(2-furyl)phosphine at 25-65 deg.C, protected from atmos.oxygen, for 1-75 hrs; and (iii) recovering (I) from the reaction mixt. R1 = opt. substd., 1-alkyl, opt. conjugated 1-polyalkenyl, 1-alkynyl, phenyl, Het or Het-CH2; Het = 2-, 3- or 4-pyridyl, 2-iomidazolyl, 2-thiazolyl, 2- or 3- furyl, 2-pyrryl 2-thienyl; Q = H, t-butoxycarbonyl, a silyl protecting gp.; or the acyl gp. of a known 7-acylamino cephalosprin antibiotic; aryl and heteroaryl gps. may be substd. by 1-3 alkyl, OH, alkoxy, halo, amino,alkylamino, dialkylamino, NO2, COOH, alkoxycarbonyl and CN gps. |
| priorityDate | 1988-04-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 129.