| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0ddb9f3656270bc5410be3679322fead |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K5-06017
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K5-0222
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K5-06026 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K5-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K5-062
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K5-06 |
| filingDate |
1998-07-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2006-02-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d7a626548184cd593cd36d7da78bc158
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_76c16123b3822661a07d1a127dd29a48
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5a73726c157d976dcd5f2e2185982e70
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b9a15a08acd883d09c5da005b0e80663
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c29b5055f758caa81388d952ffdf5c55 |
| publicationDate |
2006-02-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
DE-69830307-T2 |
| titleOfInvention |
PROCESS FOR PREPARING PHARMACOLOGICALLY COMPATIBLE SALTS OF N- (1 (S) -ETHOXYCARBONYL-3-PHENYLPROPYL) -L-ALANYL AMINO ACIDS |
| abstract |
Preparation of salts of N-(1(S)-ethoxycarbonyl-3-phenylpropyl)-L-alanyl amino acid derivatives of formula (R1)NH-CH(R2)-CO2H (I) comprises: (a) condensing an amino acid with N-(1(S)-ethoxycarbonyl-3-phenylpropyl)-L-alanine N-carboxyanhydride of formula (II), under basic conditions; (b) decarboxylating the condensate under neutral to acidic conditions to give (I); and (c) and converting (I) to its salt. Steps (a), (b) and optionally (c) are carried out in aqueous liquid to inhibit the formation of by-products of formula (III): -N(R1)CH(R2)-C(O)- = e.g. group of formula (i). |
| priorityDate |
1997-07-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |