http://rdf.ncbi.nlm.nih.gov/pubchem/patent/DE-69533178-T2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_24e76490bed88751680a5fef9bc73892 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J3-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J53-002 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J7-0045 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-57 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J53-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-57 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J75-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J71-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J7-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J- http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-56 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K- |
| filingDate | 1995-04-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2005-07-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_655c2f442b601b7af2f58636a3a3293f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_64978bae421e1ec447e0f0b9486466df |
| publicationDate | 2005-07-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | DE-69533178-T2 |
| titleOfInvention | 6 beta-hydroxy-6 alpha, 17 alpha-dimethylpregn-4-ene-3,20-dione, as an inhibitor of smooth muscle cell proliferation |
| abstract | A process for the production of medrogestone, in which, in an intermediate step, the solvate 3 beta ,5 alpha ,6 beta -trihydroxy-6 alpha ,17 alpha -dimethylpregnan-20-one monomethanolate is obtained as a solid, stable compound by displacing the organic solvent from a solution of of 3 beta ,5 alpha ,6 beta -trihydroxy-6 alpha ,17 alpha -dimethylpregnan-20-one with a lower alkanol, and a Diels-Alder adduct of 6-methylene-17 alpha -methylpregn-4-ene-3,20-dione with maleic anhydride is used as an intermediate for production of the corresponding dicarboxylic acid salt for removal of 6-methylene-17 alpha -methylpregn-4-ene-3,20-dione contamination of the desired product. Another intermediate, 6 beta -hydroxy-6 alpha ,17 alpha -dimethylpregn-4-ene-3,20-dione, has been found to prevent smooth muscle proliferation and is useful in the treatment of atherosclerosis and restinosis. |
| priorityDate | 1994-05-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
| Predicate | Subject |
|---|---|
| isDiscussedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID468142931 |
Total number of triples: 26.