| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_81c150af8961fd5ae4f74c3565019f3d |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02E50-10 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H15-252
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H19-048
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y101-01284
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C219-34
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D203-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K7-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C271-18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-0036
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P17-10 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12R1-01
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12R1-07
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12R1-19
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-09
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-53
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-53
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-573
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D203-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K7-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H15-252
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H19-048
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C219-34
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P17-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C271-18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P21-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P7-10 |
| filingDate |
1992-10-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2007-10-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6344d17f1832b1fadbbbef5531b1f77e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b01023dfa8f77aeffe4674b5fa2c3878
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e4992579eda81368f47ac1b639d57687
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1cc4089c245f898bbe773c93ebad6d21
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4740a6ff6ee5dca2303fd3ec58390450
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dcf1f9907f12c488ba25e8a41300db97
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d987fea4fee462e0ad0fb653d28ca448
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d9a452d8d3d449dc640c7c1792de8096
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_368b8d16418dbeca487e8979631b470f |
| publicationDate |
2007-10-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
DE-69233669-T2 |
| titleOfInvention |
BACTERIAL NITROREDUCTASE TO REDUCE CB 1954 AND ANALOGUE IT INTO A CYTOTOXIC FORM |
| abstract |
The invention provides a nitroreductase, obtainable from a bacterium having the following characteristics as exemplified by examples isolated from Escherichia coli B and Bacillus amyloliquifaciens: 1. It is a flavoprotein having a molecular weight in the range 20-60 Kilodaltons; 2. It requires either NADH or NAD(P)H or analogues thereof as a cofactor; 3. It has a Km for NADH or NAD(P)H in the range 1-100<0>M; and 4. It is capable of reducing either or both nitro groups of CB 1954 and analogues thereof to a cytotoxic form e.g. the hydroxylamine. The sequence of one such nitroreductase is shown in Seq. ID No.1. The nitroreductase may be conjugated to a tumor targeting agent such as a monoclonal antibody and used to convert prodrugs into active antitumour agents. Such prodrugs and drugs are also provided. |
| priorityDate |
1991-10-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |