| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_12a9e9ce63eb0bbf3658453fb50a6d9b |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2770-24222 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-506
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-005 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-50 |
| filingDate |
2003-10-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2009-01-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e2f17acaa200eecc25db53d69e5ce18d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b122ecdfc1fc0e0e39016d5640d1e7fb
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ef5b39f56f8fcd0ec59b823ba9ee1444
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9b3869ad3b4de3d464cf766b881185c5
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8fa8cfdfce6f7a6f6cd9b866b21eebbe |
| publicationDate |
2009-01-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
DE-60318954-T2 |
| titleOfInvention |
INHIBITOR RESISTANT HCV NS3 PROTEASE |
| abstract |
An inhibitor-resistant HCV NS3 protease is provided which is useful to screen for compounds having therapeutic value against drug resistant HCV strains. In particular, the inhibitor-resistant HCV NS3 protease comprises an amino acid sequence which is mutated in the substrate binding pocket thereof rendering the protease resistant to inhibitor. In a specific aspect of the present invention, at least one of the amino acids at position 155, 156 and 168 of the HCV NS3 protease is mutated to yield an inhibitor-resistant protease. |
| priorityDate |
2002-10-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |