| abstract |
Fatty acid amide derivatives (I) are new. Fatty acid amide derivatives of formula (I) and their stereoisomers and salts are new. [Image] A : C nH (2n-2m)-CH 3; n : 4-22; m : number of unsaturated bonds and is 0-7; l : 0-10; s : 0; p+q : 4-5; or s : 1; and p+q : 3-4; R : 1-10C alkyl; and R AH or 1-10C alkyl. ACTIVITY : Antiaggregant; Antiinflammatory; Cardiant; Antiarteriosclerotic; Cerebroprotective; Vasotropic; Thrombolytic; Antianginal; Hepatotropic; Antilipemic. MECHANISM OF ACTION : Cytokine-Antagonist; TNF-Antagonist-alpha ; PDGF-Antagonist; Cholesterol-Antagonist. In assays, (4Z,7Z,10Z,13Z,16Z,19Z)-N-[2-(1-methylpyrrolidin-2-yl)ethyl]docosahexaenamide (Ia) inhibited platelet aggregation with an IC 5 0 of 1.5 MicroM, compared to 5.0 MicroM for indomethacin. |