abstract |
The present invention provides novel thienopyridines, where such compounds of Formula 1 are pharmacologically useful inhibitors of Protein Tyrosine Phosphatases (PTPase's) including PTP1B, T cell PTP; wherein X, R1, R2, R3 and R4 are defined more fully in the description. The compounds are useful in the treatment of type diabetes, type 2 diabetes, impaired glucose tolerance, insulin resistance, obesity, and other diseases. |