http://rdf.ncbi.nlm.nih.gov/pubchem/patent/DE-60115419-T2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_938a6d7a15cbc93a74abe1953eb25d47 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D237-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D237-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D237-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-04 |
| filingDate | 2001-04-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2006-08-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_aa868a9c3675a65b016b073d53daa16c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_896f49ec57fc8258f0f9a91591420ed7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dc27a3c3673d16eddf79d30d2fe7cc86 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d7879dff63ffb1da5cc45855a4177301 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2aa78d9abc9dfb219977682c8ae6f968 |
| publicationDate | 2006-08-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | DE-60115419-T2 |
| titleOfInvention | ASSYMETRIC SYNTHESIS OF PIPERAZIC ACID AND ITS DERIVATIVES |
| abstract | This invention provides a concise, asymmetric synthesis of piperazic acid and derivatives thereof, whereby either the (3S)- or (3R)-enantiomeric form may be obtained with high optical purity. (3S)-piperazic acid is derived from D-glutamic acid through an (R)-2,5-dihydroxyvalerate ester intermediate. After the hydroxy groups are converted to suitable leaving groups, such as mesylates, the ester is treated with a bis-protected hydrazine to provide the desired (3S)-piperazic acid derivative. The (3R) enantiomer of piperazic acid may be similarly obtained starting with L-glutamic acid. The method may also be used to obtain piperazic acid derivatives that have moderate optical purity or are racemic. By this method, piperazic acid derivatives may be obtained that are useful as intermediates for pharmacologically active compounds. For example, certain intermediates of this invention are useful for preparing caspase inhibitors, particularly inhibitors of ICE, through additional steps known in the art.</PTEXT> |
| priorityDate | 2000-05-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 38.