| abstract |
Novel neovascularization inhibitors are constructed to provide antitumor agents which are superior in safety to conventional antitumor agents, are surely efficacious and can be administered over a prolonged period of time. Namely, indole compounds represented by general formula (I) or pharmacologically acceptable salts thereof or hydrates of the same wherein R<1> represents hydrogen, etc.; R<2> and R<3> are the same or different and each represents hydrogen, etc.; R<4> represents hydrogen or lower (C1-4) alkyl; and the ring A represents cyanophenyl, etc., provided that the following cases are excluded; the one where R<1>, R<2> and R<3> are all hydrogen atoms; the one where R<2> and R<3> are both hydrogen atoms; and the one where the ring A is an aminosulfonylphenyl group and R<1> and R<2> are both halogen atoms; and provided that when the ring A is a cyanophenyl, 2-amino-5-pyridyl or 2-halogeno-5-pyridyl group and R<1> is a cyano group or a halogen atom, then at least one of R<2> and R<3> is not hydrogen. <CHEM> |