http://rdf.ncbi.nlm.nih.gov/pubchem/patent/DE-60027546-T2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8f4c2477bdea308bc9dec3feded37457 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-53 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-549 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D285-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-5395 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D249-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D271-113 |
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D271-10 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D285-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-5395 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-53 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D253-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D285-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-549 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D271-113 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D249-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D273-04 |
| filingDate | 2000-02-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2007-04-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bd5a92bc1e220dac679f68e04e2e5423 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ce33dab5680ca63cfb5eb441f0ac0d4e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3792eaeb0550253d0c51bc2c1f0aec17 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0a84df03848f8fa6c204685147651eaa http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2f20c681d4af31e962697685a29f2527 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2929f1523873079d567ea1c4e167a916 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d20185d9469ba7e72d74bd7af6559e7e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c3c2486e15324860f3ded31f246d5492 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_70a2eaf9aed79f7d4f3a97f41bb3f327 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c50fa45fd58a655279a6b228b7ffc5cf |
| publicationDate | 2007-04-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | DE-60027546-T2 |
| titleOfInvention | Heterodiazinon DERIVATIVES |
| abstract | The present invention provides a novel compound having an excellent 2-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptor antagonistic action, particularly a therapeutic, preventing and ameliorating action useful for cerebral ischemia, cerebrospinal injuries, Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, Huntington's chorea, epilepsy, pain, spastic paralysis, multiple sclerosis etc. That is, the present invention provides a heterodiazinon compound represented by the following formula (I), a pharmacologically acceptable salt thereof or hydrates thereof. <CHEM> Wherein A represents an oxygen atom, a sulfur atom or a group represented by the formula >NR<3> (wherein R<3> represents hydrogen atom or a lower alkyl group); R<1> and R<2> are the same as or different from each other and each represents an optionally substituted aryl group, an optionally substituted heteroaryl group, an optionally substituted aralkyl group, an optionally substituted heteroaryl alkyl group, an optionally substituted aryl alkenyl group, an optionally substituted heteroaryl alkenyl group, an optionally substituted piperidyl group, an optionally substituted piperazinyl group; a morpholinyl group, an optionally substituted lower cycloalkyl group, a tetrahydrofuranyl group, a tetrahydropyranyl group, an adamantyl group, an optionally substituted amino group or an optionally substituted amide group; and R<4> and R<5> are the same as or different from each other and each represents hydrogen atom, hydroxy, a halogen atom, nitrile group, nitro group, a lower alkyl group, an aryl group or a heteroaryl group, provided that the compounds represented by the following formula (II): <CHEM> (wherein R<11> and R<12> are the same as or different from each other and each represents hydrogen atom, fluorine, chlorine, bromine, iodine, a C1-C2 fluoroalkyl group, a C1-C2 chloroalkyl group, a C1-C2 bromoalkyl group, a C1-C6 alkyl group, a C3-C6 cycloalkyl group, a C7-C9 aralkyl group, phenyl group, a C1-C6 alkoxy group, a C1-C6 alkylthio group, a C1-C6 alkylsulfinyl group, a C7-C9 aralkoxy group, phenoxy group, phenylthio group, phenylsulfonyl group, alkali metal carboxylate C2-C5 alkoxycarbonyl group or a group represented by the formula -N(R<15>)R<16> (wherein R<15> and R<16> are the same as or different from each other and each represents hydrogen atom or a C1-C2 alkyl group); and R<13> and R<14> are the same as or different from each other and each represents a C1-4 alkylsulfonyl group, nitro group, a group represented by the formula -OCHnX3-n (wherein X represents fluorine, chlorine, bromine or iodine; and n is any of integers 1 to 3) or a group having the same meanings as the definitions of R<11> and R<12>) are excluded. |
| priorityDate | 1999-02-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 69.