| abstract |
The invention concerns novel 4-aminopyridazines of general formula, (I), in which R<1> means the group R<2>-SO2-O- or R<2>-SO2-NR<3>, wherein R<2> means a cycloalkyl group, an unsubstituted or substituted aryl or heteroaryl group, R<3> means a hydrogen atom, an alkyl or alkyloxyalkyl group, which can be unsubstituted or substituted one or more times by hydroxy groups, wherein the hydroxy groups can be substituted by alkyl, hydroxyalkyl, alkyloxyalkyl, hydroxyalkyloxyalkyl or alkylcarbonyl groups and wherein two vicinal hydroxy groups can each be linked by alkylidene groups, as well as hydrates, solvates and physiologically compatible salts thereof. The invention further concerns the optically active forms, racemates and diastereomer mixtures of these compounds, a method of preparing them and drugs containing these compounds and having a thrombin-inhibiting effect. |