| abstract |
Benzo-fused 5-membered heterocyclic cpds. of formula (I) and their salts are new: X = N or CR6; Y = O, S or NR7; A + B = a bond, or A=B=H when X=CR6 and Y = NR7; R1-R6 = substits. such that (a) one is CON=C(NH2)2; (b) up to two are selected from CN, NO2 N3, 1-4C alkoxy and CF3; (c) up to one is ZCnH2nR8; and (d) the rest are selected from H, halogen and 1-6C alkyl; n = 0-10 and one C atom in CnH2n may be replaced by O, S or N; R8 = H; 2-6C alkenyl; 3-10C cycloalkyl, which may be substd. by 1-4 Me gps. or an OH gp. or may contain a CH=CH gp. and in which a CH2 gp. may be replaced by O, S or N; or phenyl substd. by 0-3 of halogen, CF3 S(O)sMe, (W)yR9*, CmF2m+1*, naphthyl*, pyridyl*, quinolyl* and isoquinolyl*; s = 0-2; R9 = H, Me or Et; W = O or NR10; R10 = H or Me; y = 0 or 1; m = 1-3; Z = CO, CH2, (CR11OH)q, O, NR12, S(O)s or SO2NR13; q = 1-3; R11 and R12 = H or Me; R13 = H or 1=4C alkyl; R7 = H, 1-10C alkyl, 2-10C alkenyl or CnH2nR8. (N.B., many definitions are ambiguous through lack of conjunctions; in particular, the asterisked substits. may be definitions of R8). |