http://rdf.ncbi.nlm.nih.gov/pubchem/patent/DE-4239946-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d5fe74855697fef20a2e98a9b005db19 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J53-004 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J53-00 |
| filingDate | 1992-11-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_725c2c24cc76e9b1fddb05c4d417cac8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2d9570eb3b52cacd3285a265e244294e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ef3747bb0abcb26c4ab6fe1f5cb6dcfb |
| publicationDate | 1994-06-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | DE-4239946-A1 |
| titleOfInvention | Estrane derivatives with a 14alpha, 15alpha-methylene group and process for their preparation |
| abstract | Prepn. of 14alpha,15alpha-methylene-estrane derivs. of formula (Ia)-(Id) comprises: (a) methylenating a 3-alkoxy-estra-1,3,5(10),8,14-pentaen-17alpha-ol of formula (II); (b) oxidising the resulting 3-alkoxy-14alpha,15alpha-methylene-estra-1,3,5(10) 8-tetraen-17-alpha-ol of formula (III); (c) reducing the 3-alkoxy-17-oxo-14alpha,15alpha-methylene-estra-1,3,5(10),8-tetraene of formula (IV) obtd.; and opt. subjecting the resulting 3-alkoxy-14alpha,15alpha-methylene-estra-1,3,5(10),8-tetraen-17beta-ol of formula (Ia) to (d) ether cleavage to give 14alpha,15alpha-methylene-estra-1,3,5(10),8-tetraene-3,17beta-diol of formula (Ib); or e) redn. to a 3-alkoxy-14alpha,15alpha-methylene-estra-1,3,5(10)-trien-17beta-ol of formula (Ic) followed by ether cleavage of the latter to 14alpha,15alpha-methylene-estra-1,3,5(10)-triene-3,17beta-diol of formula (Id). R = lower alkyl. (Ia), (Ib) and (IV) are new. (Ic) and (Id) are described in DD 145919. USE/ADVANTAGE - (Ia)-(Id) and (IV) are anti-fertility agents. The method is more effective and cheaper for the prodn. of (Ic) and (Id) than that described in DD 145919, esp. as fewer steps are required. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-0047603-A3 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-9501988-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-0047603-A2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8026229-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-9928337-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-9513076-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-9942108-A1 |
| priorityDate | 1992-11-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 73.