http://rdf.ncbi.nlm.nih.gov/pubchem/patent/DE-4223163-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c7b3bac2bf96ea816a5dd40d7913d6c1 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-365 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-35 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-37 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-37 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-365 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-35 |
| filingDate | 1992-07-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1994-01-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | DE-4223163-A1 |
| titleOfInvention | Use of 4,5,6,7-substituted benzofurans for the manufacture of a medicament for the treatment of demyelinating diseases |
| abstract | Treating demyelination disorders comprises admin. of a benzofuran, psoralen or furochromone deriv. (I). in (I), R1, R4 = H; 1-5C alkoxy; or benzyloxy; R2 = 2-4C acyl or benzoyl; and R3 = OH; 1-5C alkoxy; or benzyloxy; or R2 and R3 together are -CH=CH-C(O)-O- or-C(O)-CH=C(R)-O-(R=H or 1-3C alkyl). 5-Methoxy-posoralen (IA), 5-acetyl-6-benzyloxy-4,7-dimethoxy-benzofuran (IB) and 5,8-dimethoxy-2-methyl-furochromone (IC) at 100 micromol/l blocked calcium flow in intact myelinised nerve fibres in vitro by 76%, 75% and 20% respectively. USE/ADVANTAGE - Cpds. (I) are calcium channel blockers used to treat conditions resulting from loss or destruction the medullary sheath of myelinised nerves. They are esp. effective in the treatment of multiple sclerosis (MS) where they control symptoms well. Effects are usually seen 2-3 hrs. after admin. and last 1-2 days. No details are given w.r.t. formulations, mode of admin. or dosage. Cpds. (I) do not have the side effects associated with the use of 4-aminopyridine. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109432088-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2004096217-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1796674-A2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1796674-A4 |
| priorityDate | 1992-07-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 42.