http://rdf.ncbi.nlm.nih.gov/pubchem/patent/DE-4220320-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f8dbdfc93841b3d731fbab7ea48b412a |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-44 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-47 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-44 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-47 |
| filingDate | 1992-06-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1afe184f674c3c78ba7299893b651861 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a3fecd70a170aa52dc92ddef38679ec0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9210f26d29999096078da0990cf0ae3a |
| publicationDate | 1993-12-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | DE-4220320-A1 |
| titleOfInvention | Use of condensed bis (3,4-dihydro-1-pyridinyl) methanes for the preparation of antiproliferative agents |
| abstract | The use of fused-ring dihydro pyridine derivs. of formula (I) or their acid-addn. salts for preparing medicaments with antiproliferative activity is claimed. A and B = benzo or thieno; R2 and R3 = H or 1-5C alkyl, or CR2R3 is a 5- or 6-membered carbocyclic ring; R6 and R7 = gps. as defined for R2 and R3; R11 = 1-4C alkyl, halogen, OH, 1-4C alkoxy, NH2, SMe, OSO2Me or NHSO2Me, or adjacent R11+R11 = OCH2O or OCH2CH2O; R12 = gps. as defined for R11; m and n = 0-3, but m is not 3 when A = thieno and n is not 3 when B = thieno; R1 = H, 1-10C alkyl, phenyl, phenyl(1-5C)alkyl, 1-4C alkoxy or NHCOX (X = 1-5C alkyl); R5 = H, 1-4C alkyl or CH2OH. Pref. (I) are of formula (IA). R1 = H, 1-6C alkyl or NHCOMe; R5 = H, Me or CH2OH; R2 and R3 = H or R2+R3 = (CH2)4; R6 and R7 = H or R6+R7 = (CH2)4. Esp. R1 = H, R5 = H, R2+R3 = (CH2)4 and R6+R7 = (CH2)4. USE/ADVANTAGE - (I) are non specific cation channel blockers with 5-100 times the activity of verapamil against various human tumour cell lines. |
| priorityDate | 1992-06-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 43.