| abstract |
The invention concerns a method for the determination of hirudin and synthetic thrombin inhibitors in blood or in constituents of blood. In this method, a prothrombin intermediate, a compound which splits prothrombin into meizothrombin, a salt thereof or a mixture of these compounds plus, optionally, buffers and/or other customary additives are added to the blood or blood constituents and the time from addition to the point at which coagulation begins is measured. The invention also concerns means for carrying out the method, the means including a prothrombin intermediate, a compound which splits prothrombin into meizothrombin, a salt thereof or a mixture of these compounds plus, optionally, buffers and/or other customary additives. |