http://rdf.ncbi.nlm.nih.gov/pubchem/patent/DE-4203548-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0efa077d881a96aeb1e29b21ef1bbb58 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K7-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K7-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-12 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K7-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K7-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F9-12 |
| filingDate | 1992-02-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3abe270f8a5797b8da4ca41ac48b99e9 |
| publicationDate | 1993-08-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | DE-4203548-A1 |
| titleOfInvention | FMOC PHOSPHOTYROSINE, ITS PREPARATION AND ITS USE FOR THE PREPARATION OF PHOSPHOTYROSINE PEPTIDES |
| abstract | Fmoc-phosphotyrosine Fmoc-Tyr(PO(OH)2)OH (I) is new. USE/ADVANTAGE - (I) is used for the prodn. (claimed) of O-phosphotyrosine-contg. peptides which are model substrates for tyrosine kinase and phosphatase determinations. (I) gives better selectivity, purity and yields of O-phosphotyrosine-contg. peptides by avoiding the introduction of a protected phosphate gp. as required in prior art methods. In an example, a soln. of Fmoc-OSu (II) (0.95 mmol) in acetone (5ml) was added to phosphotyrosine (III) (1 mmol) in 10% Na2CO3 soln. (4-5ml) at room temp. and the mixt. was stirred for 24 hrs., acidified (HCl) to pH 2 and evaporated. The residue in H2O was extracted and gave, after drying, evapn. and recrystallisation (ethyl acetate-hexane), Fmoc-phosphotyrosine (I) (0.55mol; 55% yield). |
| priorityDate | 1992-02-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 67.