http://rdf.ncbi.nlm.nih.gov/pubchem/patent/DE-4203201-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f8dbdfc93841b3d731fbab7ea48b412a |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C317-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C317-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D311-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C257-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D307-79 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C323-62 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C317-44 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-78 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C323-20 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C323-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C257-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D311-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C317-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C317-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C317-44 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D307-79 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C323-62 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D213-78 |
| filingDate | 1992-02-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5d91f09c86847b02e6efb7dff687ac53 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_61d2b546009cc3f438a24f1adeb3d967 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fcf7fa805648e14d00a6943859aa637d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c986e906ab9df21e54e6cc5f91313e27 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_705dfcdb1f0ce64b7c3252a525c2a3c3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ef146fa7637a4a87f8c54d0bde1a20d7 |
| publicationDate | 1993-08-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | DE-4203201-A1 |
| titleOfInvention | NEW AMIDINE DERIVATIVES, THEIR PREPARATION AND USE |
| abstract | Amidino-benzene, pyridine, thiophene or naphthalene derivs. of formula (I), as racemates or in enantiomerically pure or enriched form, opt. as diastereomer pairs or as cis- or trans-isomer, and their salts are new. In formula (I), R1, R2 are e.g., CF3, halogen, R5, OR5, COR6, SR6, SOR6, SO2R6, etc.; or R1+R2 on adjacent C is CH=CH-CH=CH, OCH2CH2, OCH2O, OCH2CH2O, etc.; R3 is e.g. halogen, OH, CF3, R5, OR6, COR6, SR6, SOR6, SO2R6; provided that R3 can only be H when at least one of R1 and R2 is other than H; R4 is halogen, R5 or OR5; R5 is H, 1-12C alkyl or phenyl (opt. substd. by halogen, 1-4C alkyl, 1-4C alkyl, 1-4C alkoxy or 2-5C acyl); R6 is 1-12C alkyl or phenyl (opt. substd. by halogen, 1-4C alkyl, 1-4C alkoxy or 2-5C acyl); A is X1-A1-X2, X2-A2-X3, X4-A2-X2, (CH2)x-NHCO-(CH2)y-X2 or CH=CH-A2X2; x is 1 or 2; y is 1-3; B is CH=CH, CH=N, S or o-phenylene; A1 is 2-4C alkylene, cis- or trans-CH=CHCH2, CH2CCCH2, -CH2-cyclohexylene-CH2 or -CH2-phenylene-CH2-; A2 is 1-5C alkylene; X1 is O, NH, S, SO, SO2, CO or CH2; X2 is O, NH or S; X3 is NHCO, CONH or SO2NH; and X4 is NHCO, CONH, NHSO2 or SO2NH. USE - (I) are leukotriene B4 (LTB4) antagonists and are used for prodn. of medicaments for treatment of diseases involving inflammatory and/or allergic reactions, esp. asthma, ulcerative colitis and psoriasis. (I) are administered topically, orally, transdermally, intranasally, parenterally or by inhalation, opt. in combination with other drugs, e.g., antiallergics, secretolytics, beta(2)-mimetics, steroids, antihistamines or PAF antagonists. Typical dose is 10-250 (pref. 20-200)mg orally or 2-20mg by inhalation. Typically EC50 for inhibition of LTB4-induced neutrophil aggregation is 0.5-0.05 micro-M. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-9931092-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-9932125-A1 |
| priorityDate | 1992-02-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 88.