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filingDate 1991-12-18-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a0f216d3f0d58c8876b33596fa37c680
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publicationDate 1993-06-24-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber DE-4142452-A1
titleOfInvention AGENT FOR STIMULATING THE DIVIDING ACTIVITY OF ANIMAL CELLS
abstract An agent for stimulating animal and human cell division has applications in the areas of biological-medical fundamental research, in biotechnology and in the pharmaceutical industry. The disclosed agent is characterized by nucleotide sequences with a complementary (anti-sense) sequence to specific domains of the mRNA of tumor suppressor genes or other genes having a negative effect on cell division. Synthetic oligonucleotides having at least 15 nucleotides, preferably 18 to 21 nucleotides, in length are preferably used as a nucleotide sequence. An amount of the agent comprised between 5 and 30 mu M is added to the culture medium and its concentration should remain essentially constant during cultivation.
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