http://rdf.ncbi.nlm.nih.gov/pubchem/patent/DE-4122911-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5c24684033fba97d1ad845ce453a57e3 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C2601-14 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D217-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C269-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C271-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C271-22 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C271-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C271-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D217-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C269-06 |
| filingDate | 1991-07-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1993-01-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | DE-4122911-A1 |
| titleOfInvention | METHOD FOR DIASTEREOSELECTIVE REDUCTIVE PINAKOL COUPLING OF HOMOCHIRAL (ALPHA) -AMINOALDEHYDES |
| abstract | The prepn. of diaminodiol derivs. of formula (I) and their enantiomers and physiologically acceptable salts comprises treating homochiral alpha-amino-aldehyde derivs. of formula (II) with (V2Cl3(THF)6)2(Zn2Cl6) or a vanadium complex obtd. in situ from VCl3, THF and zinc dust, giving simultaneous control over all 4 centres of durality. In formulae, R1 is a side chain of a naturally or not naturally occurring alpha-amino acid; R1 and R2 = each H or D(E)n(F)o(G)p; E, F and G = each naturally or not naturally occurring aminoacid gps., aza amino acid or imino acid; n, o and p = each 0 or 1; D = R4 or a gp. of formula R4R5N-CR6R7-CO-, R4R8CH-CHR6-CO- or R4O-CHR6-CO- R4 = (a) H, COOH, 1-18C alkyl (opt. mono- or poly unsatd. and opt. substd. with up to 3 opt. different gps. chosen from mercapto, OH, 1-7C alkoxy, carbonoyl, 1-8C alkanoyloxy, carboxy, 1-7C alkoxycarbonyl, F, Cl, Br, I, amino amidino, etc. (b) R4aW (where R4a is as defined for R4 under (a) and W is CO, CS, OCO, SO2, SO, S, NHSO2, NHCO, CH(OH), N(OH) or COV; or where R4 together with R8 and the atoms to which they are attached form a mono or bicyclic, satd. or partially unsatd. ring system with 5-12 ring members, contg. apart from C, opt. one S atom which is opt. oxidised to sulphoxide or sulphone; (c) glycosyl, pref. glucofuranosyl, or glucopyranosyl, etc. (d) an amino protecting gp. R5 = H or 1-8C alkyl, or together with R6 and the atoms to which they are attached, forms a mono or bicyclic, satd. or partially unsatd. ring system contg. 5-12 ring members; R6 = as defined for R4 under (a); OH or 1-4C alkanoyloxy; or R6 and R7 and the atoms to which they are attached, form a cyclic, satd. or partially unsatd. ring system with 3-12 ring members; or R6 and R8 and the atoms to which they are attached form a mono or bicyclic, satd. or partially unsatd. ring system contg. 5-12 ring members which contains in addition to C, 1S which is opt. oxidised to sulphoxide or sulphone; or contains one N and the ring system is opt. substd. with amino; R7 = H or 1-6C alkyl; and R8 = H, OH, 1-4C alkanoyloxy or 1-8C alkyl; |
| priorityDate | 1991-07-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 248.